From the Heraklion Airport:

Follow the signage upon leaving the airport, directing you south towards the National Road for a distance of 78 km.
Prior to the bridge, make a right turn onto Route BOAK/E75 of the National Road leading to Rethymno, covering a distance of 73 km.
Continue in a straight direction, heading west, until you encounter the sign for Sfakaki, Old National Road on your right-hand side, approximately 5 km away.
Maintain a straight course until you arrive at Galeana Mare Hotel, situated on your right.

From the Chania Airport:

Head east for 190 m.
Turn left onto Road Souda Airport and continue for 550 m.
Turn right on Road Souda Airport, covering 650 m.
Turn left to stay on National Road Souda Airport and go through 1 roundabout for 6.9 km.
At the roundabout, take the 2nd exit onto provincial road Suda-Korakies for 1.7 km.
Continue to Akrotiri for 3.1 km.
Turn left onto Mavridakis and travel 900 m.
Turn right onto Souda Avenue for 300 m.
Turn left onto E75 for 900 m.
Turn left onto the A90 ramp to Rethymno / RETHYMNO for 180 m.
Enter the VOAK/E75/A90 and cover 55.6 km.
Cross over the city of Rethymno until you see the sign for Amari, turn right under the bridge for 500 m.
Turn right onto sign Misiria and maintain a straight course for 2 km.
Continue straight until you reach Galeana Mare Hotel, situated on your left.